Soft tissue sarcoma is a cancer of the soft tissues of the body. These include the muscles, tendons, fat, blood vessels, lymph vessels, nerves and tissues around the joints. This is different from the more well-known types of cancer of the bowel, breast, lung, prostate, cervix and skin which are all cancers of the surface lining of the affected organ. There are many different types of sarcomas and all of them are rare. All together, they constitute about 1% of all cancer. They can form almost anywhere in the body but are most common in the limbs, body wall, abdominal and chest cavity and head and neck.
Soft tissue sarcoma does not generally include sarcoma of bone.
When it occurs in the limbs, neck or body wall, soft tissue sarcoma most commonly presents as a painless lump. In the abdomen or chest cavities, sarcoma may not become apparent until it is very big, at which point may felt as a lump or it may cause pain or functional problems by pressing on nearby organs.
Soft tissue sarcoma is diagnosed with a biopsy. There are two types of biopsy in common use:
The process of staging informs prognosis and treatment. Information required for staging includes the size and grade of the tumour, and whether it has spread to surrounding organs, the nearby lymph nodes, or organs distant to the tumour like the liver and lungs. A number of tests are required to stage the sarcoma including:
There is no standard staging system for soft tissue sarcoma of the head, neck, chest or abdomen.
For soft tissue sarcoma of the trunk, arms and legs in adults, the following stages are used:
For soft tissue sarcoma of the retroperitoneum, the following stages are used:
Soft tissue sarcoma is treated by teams of highly specialised practitioners who may include surgical oncologists, medical oncologists, radiation oncologists, radiologists, nuclear medicine physicians, pathologists, nurses, occupational and physiotherapists, speech therapists and dieticians.
There are three standard types of treatment for soft tissue sarcoma. They are surgery, chemotherapy and radiotherapy. In addition, there are new types of treatments that are being tested as part of clinical trials. These therapies complement each other and are used together in combinations that depend on the particular type, site and stage of the sarcoma.
Surgery Surgery is the most common form of treatment for soft tissue sarcoma. For some sarcomas, surgery is the only treatment that is required. The aim of sarcoma surgery is the complete removal of the tumour with a margin of healthy tissue.
When sarcoma occurs in the limbs, the aim is to remove the tumour and preserve the function of the limb. If the tumour cannot be removed, the function of the limb cannot be preserved, or the tumour recurs in a limb after it has been treated, amputation is occasionally required. If the sarcoma has spread to nearby lymph nodes, they may also need to be removed.
If the tumour occurs within a body cavity, achieving a margin of healthy tissue can be challenging and may mean the removal of organs or parts of organs which are affected by tumour.
Radiotherapy uses high energy radiation to kill cancer cells. It can be given by a machine external to the body, or by radioactive substances implanted in needles, seeds, wires or catheters placed near to or directly into the sarcoma.
In the treatment of soft tissue sarcoma, radiotherapy is used in a few different ways. Occasionally it is used as definitive therapy to kill the tumour. More frequently it is used prior to, or after surgery. It may aid surgical resection by shrinking the tumour and may also prevent it from recurring once therapy is complete. It is also used to treat deposits that have spread away from the main tumour. The method and timing of radiotherapy depends on the type and stage of the cancer being treated.
Chemotherapy is cancer treatment that uses drugs to kill or stop the growth of cancer cells. These drugs commonly target the cancer cells’ ability to divide, destroy its DNA or hamper its’ metabolism. Chemotherapy is occasionally used prior to surgery in order to shrink the tumour and make it more easily removable. It is more commonly used after surgery to mop up any cancer cells that may have spread around the body prior to the main tumour being removed.
These are not new treatments, but new anti-cancer drugs are rekindling interest in these methods. Isolated limb perfusion and infusion are techniques where the blood supply to an affected limb is temporarily interrupted with a tourniquet. High-dose chemotherapy is then injected directly into the blood vessel of that limb. Hepatic artery and portal vein infusion chemotherapy uses a similar principle to treat sarcoma that started in or spread to the liver.
Numerous agents have been tested that directly target known genetic abnormalities within the sarcoma. Success with these agents has been variable and they are frequently the subject of clinical trials.
If you have any questions, please do not hesitate to contact us.
Ph: 02 8307 0977
Fax: 02 8088 7420
The management of sarcoma is a highly specialised area. Please refer to the following resources for more information:
This pamphlet is intended to provide you with information and does not contain all known facts about sarcoma. Treatment may have uncommon risks not discussed in this pamphlet. Please do not hesitate to ask any questions you may have.